Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.
Secondary Adrenocortical Insufficiency
What is secondary adrenocortical insufficiency?
Production of cortisol is controlled by the action of ACTH. ACTH is produced by the pituitary gland. This gland is controlled by the hypothalamus in the brain. If either the hypothalamus or pituitary gland is damaged, less ACTH is produced. This can lead to problems with the adrenal glands and reduced cortisol production.
What causes it?
Secondary adrenocortical insufficiency may be caused by:
- A tumor of the pituitary gland or hypothalamus.
- Past radiation of the hypothalamus or pituitary gland.
- Past surgery to the pituitary gland.
- Rare conditions such as hemochromatosis, sarcoidosis, or Sheehan's syndrome (hypopituitarism). Sheehan's syndrome is sometimes caused by severe blood loss after giving birth.
What are the symptoms?
With secondary adrenocortical insufficiency, only cortisol is low. The adrenal glands can usually still make normal amounts of the hormone aldosterone. Symptoms include:
- Fatigue and muscle weakness. These may get worse over time.
- Weight loss. Profound weight loss is a prominent symptom.
- Loss of appetite.
How is it diagnosed?
Diagnosis starts with a medical history and physical exam. If your doctor suspects adrenal insufficiency, the doctor will check your blood cortisol and ACTH levels. You may have imaging tests of the adrenal glands, the pituitary gland, or the hypothalamus.
How is secondary adrenocortical insufficiency treated?
If possible, your doctor will treat the condition that is causing secondary adrenocortical insufficiency. Treatment will also include medicines like corticosteroids (hydrocortisone). You and your doctor will work together to find the dose that works best for you. It is also important to ask your doctor what to do when your body is under stress.
Current as of: April 13, 2022
Author: Healthwise Staff
E. Gregory Thompson MD - Internal Medicine
Kathleen Romito MD - Family Medicine
To learn more about Healthwise, visit Healthwise.org.
© 1995-2022 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.